p-MPPI hydrochloride

p-MPPI hydrochloride 是一种选择性的，具有高亲和力的 5-HT1A 受体拮抗剂。p-MPPI hydrochloride 能穿过血脑屏障，具有明显的抗抑郁和抗焦虑作用。

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库存: 现货

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包装

价格

促销价

数量
10mg

￥1100.00

880.00

- +
25mg

￥1962.00

1570.00

- +
50mg

￥3262.00

2610.00

- +
100mg

￥5175.00

4140.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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Background

p-MPPI hydrochloride is a selective 5-HT1A receptor antagonist with high affinity for 5-HT1A receptors. p-MPPI hydrochloride can crosses the blood-brain barrier, and has clear antidepressant and anxiolytic-like effects[1][2].

p-MPPI hydrochloride has no agonist activity in both in vitro and in vivo tests of pre- and post-synaptic 5-HT1A receptor activity[1].

p-MPPI hydrochloride (0.5-4.5 mg/kg; i.p.) shows anxiolytic-like profile in the murine elevated plus-maze[2]. Animal Model: Adult male Swiss Webster mice (aged 8-9 weeks)[2]

[1]. S?rensen E, et al. The selective 5-HT(1A) receptor antagonist p-MPPI antagonizes sleep--waking and behavioural effects of 8-OH-DPAT in rats. Behav Brain Res. 2001 Jun;121(1-2):181-7. [2]. Cao BJ, et al. Anxiolytic-like profile of p-MPPI, a novel 5HT1A receptor antagonist, in the murine elevated plus-maze. Psychopharmacology (Berl). 1997 Feb;129(4):365-71.