CB-1158 dihydrochloride

An arginase inhibitor

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库存: 现货

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数量
5mg

￥2612.00

2090.00

- +
10mg

￥4525.00

3620.00

- +
25mg

￥8850.00

7080.00

- +

已选 0 种 0 瓶

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货号: ajcx30342
CAS: N/A
别名:
分子式: C11H24BCl2N3O5
分子量: 360.04
纯度: >98%
溶解度: Water: ≥ 50 mg/mL (138.87 mM); DMSO: < 1 mg/mL (insoluble or slightly soluble)
储存: 4°C, away from moisture
库存: 现货

Background

CB-1158 is an inhibitor of arginase I and II (IC₅₀s = 0.086 and 0.296 ?M for the human enzymes, respectively).¹ It is selective for arginase I and II over neuronal nitric oxide synthase (nNOS), endothelial NOS (eNOS), and inducible NOS (iNOS; IC₅₀s = >50 ?M for all). CB-1158 reverses inhibition of T cell proliferation induced by granulocytes in vitro (IC₅₀ = 0.204 ?M). It reduces tumor growth in a CT26 murine colon cancer model when administered at a dose of 100 mg/kg twice per day.

1.Steggerda, S.M., Bennett, M.K., Chen, J., et al.Inhibition of arginase by CB-1158 blocks myeloid cell-mediated immune suppression in the tumor microenvironmentJ. Immunother. Cancer5(1)101(2017)