LY3154207

LY3154207 是一种有效的、亚型选择性的、口服的人多巴胺 D1 受体 (human dopamine D1 receptor) 正向变构调节剂 (PAM)，具有最小的变构激动剂活性 (EC50=3 nM)。

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库存: 现货

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促销价

数量
5mg

￥5175.00

4140.00

- +
10mg

￥8637.00

6910.00

- +
50mg

￥24037.00

19230.00

- +
100mg

￥34725.00

27780.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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货号: ajcx34926
CAS: 1638667-79-4
别名:
分子式: C24H29Cl2NO3
分子量: 450.4
纯度: >98%
溶解度: DMSO : 110 mg/mL (244.23 mM; Need ultrasonic)
储存: Store at -20°C
库存: 现货

Background

LY3154207 is a potent, subtype selective, and orally available human dopamine D1 receptorpositive allosteric modulator (PAM) with minimal allosteric agonist activity (EC50=3 nM)[1].

In HEK293 cells transiently expressing human, dog, rhesus monkey, and mouse D1 receptors, the EC50s of LY3154207 are 2.3 nM, 2.0 nM, 2.5 nM, and 62.1 nM, respectively[1].

[1]. Hao J, Synthesis and Pharmacological Characterization of 2-(2,6-Dichlorophenyl)-1-((1S,3R)-5-(3-hydroxy-3-methylbutyl)-3-(hydroxymethyl)-1-methyl-3,4-dihydroisoquinolin-2(1H)-yl)ethan-1-one (LY3154207), a Potent, Subtype Selective, and Orally Available Positive Allosteric Modulator of the Human Dopamine D1 Receptor. J Med Chem. 2019 Oct 10;62(19):8711-8732.