POT-4

POT-4 (AL-78898A)，一种 Compstatin 衍生物，是补体因子 C3 激活的有效抑制剂。POT-4 可用于与年龄相关的黄斑变性的研究。

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库存: 现货

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5mg

￥4525.00

3620.00

- +
10mg

￥7225.00

5780.00

- +

已选 0 种 0 瓶

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Background

POT-4 (AL-78898A), a Compstatin derivative, is a potent inhibitor of complement factor C3 activation. POT-4 can be used for age-related macular degeneration research[1][2]

A derivative of compstatin, a potent C3 inhibitor, POT-4 is a cyclic peptide that exhibits binding activity to C3, preventing cleavage to its active fragments C3a and C3b[2].

[1]. S. Kaushal, et al. Complement C3 inhibitor POT-4: Clinical Safety of Intravitreal Administration. ARVO Annual Meeting Abstract, 2009 Apr.
[2]. Robyn Troutbeck, et al. Therapeutic targeting of the complement system in age-related macular degeneration: a review. Clin Exp Ophthalmol. Jan-Feb 2012;40(1):18-26.