Inclisiran

此产品仅用于科学研究，我们不为任何个人用途提供产品和服务

可选规格

包装

价格

促销价

数量
1mg

￥11465.00

9172.00

- +
5mg

￥35280.00

28224.00

- +

已选 0 种 0 瓶

金额: ￥0.00

首页收藏

Inclisiran (ALN-PCSsc) 是一种双链小干扰 RNA (siRNA) 分子，可抑制 PCSK-9 的转录。Inclisiran 可用于高脂血症和心血管疾病 (CVD) 研究。

货号:ajcx35650
CAS:1639324-58-5
分子式:N/A
分子量：16339.00
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Inclisiran (ALN-PCSsc) is a double-stranded small interfering RNA (siRNA) molecule that inhibits the transcription of PCSK-9. Inclisiran can be used for hyperlipidemia and cardiovascular disease (CVD) research[1].

Inclisiran is a double-stranded small RNA molecule that works by blocking the transcription of proprotein convertase subtilisin kexin 9 (PCSK-9), leading to a reduction of PCSK-9 levels in the hepatocytes, resulting in an increased expression of low-density lipoprotein (LDL) receptors in the hepatocyte membrane and, as a consequence, it reduces the circulating levels of LDL cholesterol (LDL-C)[1].

[1]. Constantine E Kosmas, et al. Inclisiran for the Treatment of Cardiovascular Disease: A Short Review on the Emerging Data and Therapeutic Potential. Ther Clin Risk Manag. 2020 Oct 28;16:1031-1037.