Ispronicline

Ispronicline (TC-1734) 是一种有效的，具有口服活性的大脑选择性的 α4β2 nAChR 部分激动剂，具有增强记忆的特性和良好的耐受性。Ispronicline 高亲和力与 α4β2 nAChR 结合，Ki= 11 nM。

此产品仅用于科学研究，我们不为任何个人用途提供产品和服务

库存: 现货

可选规格

包装

价格

促销价

数量
5mg

￥987.00

790.00

- +
10mg

￥1625.00

1300.00

- +
25mg

￥3487.00

2790.00

- +
50mg

￥5712.00

4570.00

- +
100mg

￥9175.00

7340.00

- +

已选 0 种 0 瓶

金额: ￥0.00

首页收藏

货号: ajcx35898
CAS: 252870-53-4
别名: (2S,4E)-5-(5-异丙基吡啶-3-)-N-甲基戊-4-烯-2-胺,TC-1734; ACD3480
分子式: C14H22N2O
分子量: 234.34
纯度: >98%
溶解度: DMSO : 100 mg/mL (426.73 mM; Need ultrasonic)
储存: Store at -20°C
库存: 现货

Background

Ispronicline (TC-1734), an orally active, brain-selective α4β2 nicotine acetylcholine receptor (nAChR) partial agonist, has shown memory-enhancing properties in rodents and a good tolerability profile. Ispronicline binds to the α4β2 nAChR with high affinity (Ki=11 nM) and is highly selective to other nAChRs such as α7 nAChR and α3β4 nAChR[1][2].

Ispronicline (10-20 mg/kg; s.c.) induces c-Fos expression in selective regions of the rat forebrain[1]. Ispronicline pharmacokinetics (half-life of 2 h in rats) contrasts with the long-lasting improvement of working memory (18 h to 2 d)[2].

[1]. Julie Jacobsen, et al. The α4β2 nicotine acetylcholine receptor agonist ispronicline induces c-Fos expression in selective regions of the rat forebrain. Neurosci Lett. 2012 Apr 25;515(1):7-11.