NOTA 是一种双功能螯合物,可作为构建 PET 成像工具的框架。NOTA 还可以用于探针设计并通过多价效应设计信号放大。
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NOTA is a bifunctional chelate which acts as the framework to construct PET imaging tools. NOTA also can be used for probe design and signal amplification via the multivalent effect[1][2].
[1]. Singh AN, et al. Multivalent bifunctional chelator scaffolds for gallium-68 based positron emission tomography imaging probe design: signal amplification via multivalency. Bioconjug Chem. 2011;22(8):1650-1662. [2]. Liao AH, et al. Evaluation of 18F-labeled targeted perfluorocarbon-filled albumin microbubbles as a probe for microUS and microPET in tumor-bearing mice. Ultrasonics. 2013;53(2):320-327.
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