Ornidazole

An antibacterial and antiprotozoal 5-nitroimidazole derivative

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50mg

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货号: ajci4292
CAS: 16773-42-5
别名: 奥硝唑; Ro 7-0207
分子式: C7H10ClN3O3
分子量: 219.63
纯度: >98%
溶解度: ≥ 11mg/mL in DMSO
储存: 4°C, protect from light, stored under nitrogen
库存: 现货

Background

Ornidazole(Ro 7-0207) is a 5-nitroimidazole derivative with antiprotozoal and antibacterial properties against anaerobic bacteria. Target: Antibacterial; AntiparasiticOrnidazole is a drug that cures some protozoan infections. Ornidazole 1 g/day is effective for the prevention of recurrence of Crohn's disease after ileocolonic resection [1]. Ornidazole is converted to reduction products that interact with DNA to cause destruction of helical DNA structure and strand leading to a protein synthesis inhibition and cell death in susceptible organisms [2].

参考文献:
[1]. Rutgeerts, P., et al., Ornidazole for prophylaxis of postoperative Crohn's disease recurrence: a randomized, double-blind, placebo-controlled trial. Gastroenterology, 2005. 128(4): p. 856-61.
[2]. Goldstein, E.J., V.L. Sutter, and S.M. Finegold, Comparative susceptibilities of anaerobic bacteria to metronidazole, ornidazole, and SC-28538. Antimicrob Agents Chemother, 1978. 14(4): p. 609-13.