RGD (Arg-Gly-Asp) Peptides

RGD（Arg-Gly-Asp）肽是一种三肽，可有效触发细胞粘附、定位某些细胞系并引发特定的细胞反应；与整合素结合。

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货号: ajci4610
CAS: 99896-85-2
别名: 精氨酰-甘氨酰-天冬氨酸
分子式: C12H22N6O6
分子量: 346.34
纯度: >98%
溶解度: ≥ 17.3mg/mL in Water with gentle warming
储存: Store at -20°C,stored under nitrogen
库存: 现货

Background

Synthetic peptides containing the arginine-glycine-aspartate (RGD) were extensively used as inhibitors of integrin-ligand interactions in studies of cell adhesion, migration, growth and differentiation, since the RGD motif is an integrin-recognition motif found in many ligands.

In vitro: RGD peptide can induce apoptosis in the absence of signals and integrin-mediated cell clustering. Previous study demonstrates that RGD peptides promote apoptosis through activation of conformation changes enhancing pro-caspase-3 activation and autoprocessing [1].

In vivo: Anima study suggested that the RGD-4C-FITC-peptide bound to both endothelial and tumor cells in vivo and that peptide targeting should allow the delivery of therapeutic drugs to both endothelial and tumor cells [2].

Clinical trials: Currenlty no clinical data are available.

参考文献:
[1] Nature.? 1999 Feb 11;397(6719):534-9.
RGD peptides induce apoptosis by direct caspase-3 activation.?
Buckley CD1, Pilling D, Henriquez NV, Parsonage G, Threlfall K, Scheel-Toellner D, Simmons DL, Akbar AN, Lord JM, Salmon M.?
[2] Cancer Res.? 2002 Sep 15;62(18):5139-43. Arginine-glycine-aspartic acid (RGD)-peptide binds to both tumor and tumor-endothelial cells in vivo.? Zitzmann S1, Ehemann V, Schwab M.??

Protocol

Cell experiment [1]:
Cell lines	Lung fibroblasts
Preparation method	The solubility of this compound in DMSO is limited. General tips for obtaining a higher concentration: Please warm the tube at 37 °C for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below - 20 °C for several months.
Reacting condition	1 mM; 24 hrs
Applications	In lung fibroblasts, RGD peptides induced apoptosis and caspase-3 activation. Moreover, in both adherent and detached cells, RGD peptides resulted in pro-caspase-3 cleavage. Thus, RGD-containing peptides can induce apoptosis before the adherent cells detach from their substrates.
参考文献: [1]. Buckley CD, Pilling D, Henriquez NV, Parsonage G, Threlfall K, Scheel-Toellner D, Simmons DL, Akbar AN, Lord JM, Salmon M. RGD peptides induce apoptosis by direct caspase-3 activation. Nature. 1999 Feb 11;397(6719):534-9.