Atazanavir sulfate (BMS-232632-05)

An inhibitor of HIV-1 protease

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库存: 现货

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5mg

￥0.00

0.00

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10mg

￥762.00

610.00

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25mg

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0.00

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50mg

￥2287.00

1830.00

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货号: ajci4722
CAS: 229975-97-7
别名: 硫酸阿扎那韦; BMS-232632 sulfate
分子式: C38H52N6O7.H2SO4
分子量: 802.9
纯度: >98%
溶解度: ≥ 28.7 mg/mL in DMSO with gentle warming, ≥ 4.05 mg/mL in EtOH with ultrasonic and warming
储存: Store at -20°C
库存: 现货

Background

Atazanavir sulfate (BMS-232632-05) is the sulfate salt form of atazanavir, a potent protease inhibitor (IP) for the treatment of human immunodeficiency virus 1 (HIV-1) infection, which prevents the formation of mature HIV virions through the selective inhibition of the virus-specific processing of viral gag and gag-pol polyproteins in infected cells. Although it shows strong anti-HIV-1 activity with MIC₅₀ ranging from 2 to 5 nM, atazanavir has lower antiviral activity against HIV-2 isolates. Atazanavir, which is metabolized by the hepatic cytochrome P450 (CYP) system resulting in two main inactive metabolites, is also an inhibitor of CYP3A4 isoenzyme and P-glycoprotein ATP-dependent efflux pump.

Reference

[1].Robin Wood. Atazanavir: its role in HIV treatment. Expert Rev Snti Infect Ther 2008; 6(6): 785-796