MRS 1706

A selective adenosine A2B receptor inverse agonist

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1mg

￥312.00

250.00

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5mg

￥1087.00

870.00

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10mg

￥1787.00

1430.00

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50mg

￥7125.00

5700.00

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Background

MRS-1706 is a potent and selective adenosine A2B receptor inverse agonist. MRS-1706 has Ki values of 1.39, 112, 157, and 230 nM for human A2B, A2A, A1 and A3 receptors respectively[1][2].

参考文献:
[1]. Li Q, et al. ZM241385, DPCPX, MRS1706 are inverse agonists with different relative intrinsic efficacies on constitutively active mutants of the human adenosine A2B receptor. J Pharmacol Exp Ther. 2007 Feb;320(2):637-45.
[2]. Desai A, et al. Adenosine A2A receptor stimulation increases angiogenesis by down-regulating production of the antiangiogenic matrix protein thrombospondin 1. Mol Pharmacol. 2005 May;67(5):1406-13.