Calpeptin

A calpain inhibitor

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库存: 现货

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10mg

￥612.00

490.00

- +
50mg

￥1725.00

1380.00

- +
500mg

￥9437.00

7550.00

- +
1g

￥14962.00

11970.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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货号: ajci4926
CAS: 117591-20-5
别名:
分子式: C20H30N2O4
分子量: 362.47
纯度: >98%
溶解度: ≥ 87.6 mg/mL in DMSO, ≥ 96.6 mg/mL in EtOH
储存: Desiccate at 4°C
库存: 现货

Background

IC50: 5 nM for human calpain 1

Calpeptin is a calpain inhibitor.

As a calcium-dependent intracellular cysteine protease, calpain plays an key role in various cellular processes including cell differentiation, growth and apoptosis. In rheumatoid arthritis patients, over-expression of calpains are observed in arthritic synovial fluid and are thought to play critical roles in various cellular processes.

In vitro: Calpeptin reduced production of TGF-b1, IL-6, angiopoietin-1 and collagen synthesis from lung fibroblasts. Calpeptin also reduced both angiopoietin-1-dependent migration and IL-6-dependent proliferation of the cells, which could be the underlying mechanism of the preventive effect of Calpeptin on pulmonary fibrosis [1].

In vivo: The preventive effect of calpeptin has been examined on bleomycin-induced pulmonary fibrosis in mice. Histological examinations and quantitative measurements of related proteins in bleomycin-treated mouse lung tissues with or without calpeptin were performed. Calpeptin histologically ameliorated bleomycininduced pulmonary fibrosis in mice. Results showed that calpeptin decreased the expression of IL-6, TGF-b1, angiopoietin-1 and collagen type Ia1 mRNA in mouse lung tissues [1].

Clinical trial: N/A

Reference:
[1] Tabata C,Tabata R,Nakano T.? The calpain inhibitor calpeptin prevents bleomycin-induced pulmonary fibrosis in mice. Clin Exp Immunol.2010 Dec;162(3):560-7.