PSN632408

A selective agonist of GPR119

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库存: 现货

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5mg

￥725.00

580.00

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10mg

￥1212.00

970.00

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50mg

￥5362.00

4290.00

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货号: ajci4972
CAS: 857652-30-3
别名:
分子式: C18H24N4O4
分子量: 360.41
纯度: >98%
溶解度: DMF: 20 mg/ml,DMSO: 5 mg/ml,Ethanol: 20 mg/ml,Ethanol:PBS (pH 7.2) (1:6): 0.5 mg/ml
储存: Store at -20°C
库存: 现货

Background

PSN632408 is a novel, selective and small-molecule agonist of human and mouse GPR119 with EC50 values of 5.6±0.99 μM and 7.9±0.7 μM, respectively [1].

PSN632408 has been reported to activate human and mouse GPR119 in a yeast fluorimetric assay with EC50 of 5.6±0.99 μM and 7.9±0.7 μM, respectively. In HEK-OSGPR116 cells, cAMP level was dose-dependently increased by PSN632408 with an EC50 of 1.9±0.14 μM.. In vivo, PSN632408 induced food intake reduction by using a rat feeding model and acute hypophagic effects in dose-dependence [1].

参考文献:
[1] Overton HA1, Babbs AJ, Doel SM, Fyfe MC, Gardner LS, Griffin G, Jackson HC, Procter MJ, Rasamison CM, Tang-Christensen M, Widdowson PS, Williams GM, Reynet C.Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents. Cell Metab. 2006 Mar;3(3):167-75