Cathepsin G Inhibitor I

Cathepsin G Inhibitor I 是一种有效的、选择性的、可逆的、竞争性的、非肽的组织蛋白酶 G 抑制剂。

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库存: 现货

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数量
500ug

￥825.00

660.00

- +
1mg

￥1550.00

1240.00

- +
5mg

￥5625.00

4500.00

- +

已选 0 种 0 瓶

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货号: ajci4994
CAS: 429676-93-7
别名:
分子式: C36H33N2O6P
分子量: 620.64
纯度: >98%
溶解度: DMF: 5 mg/ml; DMSO: 10 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
储存: Store at -20°C
库存: 现货

Background

IC50: 53 nM

Cathepsin G (EC 3.4.21.20, chymotrypsin-like proteinase, neutral proteinase) is an enzymatic protein belonging to the peptidase or protease families. In humans, it is coded by the CTSG gene. Cathepsin G Inhibitor I is a potent, selective, reversible, competitive, non-peptide inhibitor of cathepsin G.

In vitro: Cathepsin G Inhibitor I shows reversible, competitive inhibition with IC50 and Ki values of 53 ± 12 (N = 10) and 63 ± 14 nM (N = 5), respectively. Another attribute of Cathepsin G Inhibitor I relates to its selectivity vs other serine proteases. It weakly inhibits chymotrypsin (Ki = 1.5 ± 0.2 μM), and poorly inhibits (

In vivo: Cathepsin G Inhibitor I is currently in in-vitro investigation and no animal in vivo study is ongoing [1].

Clinical trial: Cathepsin G Inhibitor I is currently in the preclinical development and no clinical trial is ongoing.

Reference:
[1] Greco MN, Hawkins MJ, Powell ET, Almond HR Jr, Corcoran TW, de Garavilla L, Kauffman JA, Recacha R, Chattopadhyay D, Andrade-Gordon P, Maryanoff BE.? Nonpeptide inhibitors of cathepsin G: optimization of a novel beta-ketophosphonic acid lead by structure-based drug design. J Am Chem Soc. 2002;124(15):3810-1.