Helioxanthin

novel inhibitor of HBV, HCV and HSV-1 virus

此产品仅用于科学研究，我们不为任何个人用途提供产品和服务

库存: 现货

可选规格

包装

价格

促销价

数量
5mg

￥2900.00

2320.00

- +
10mg

￥4137.00

3310.00

- +

已选 0 种 0 瓶

金额: ￥0.00

首页收藏

Background

Helioxanthin (ACH126447) is a novel inhibitor of HBV, HCV and HSV-1 virus with EC50 values of 1 μM, 3 μM and 2 μM, respectively [1].

Helioxanthin has shown significant antiviral effect on HBV, HCV and HSV-1 virus in vitro with EC50 values of 1 μM, 3 μM and 2 μM, respectively. In a cell culture model, the level of HBV RNA, the expression of HBV antigen and its replication were all reduced by helioxanthin. Besides, helioxanthin has been exhibited to have a low cytotoxicity on both MT-223 and CEM24 cell lines with ID50 values of 2.5 μM and 31 μM, respectively [1].

Reference:
[1] Yeo H1, Li Y, Fu L, Zhu JL, Gullen EA, Dutschman GE, Lee Y, Chung R, Huang ES, Austin DJ, Cheng YC.?Synthesis and antiviral activity of helioxanthin analogues. J Med Chem. 2005 Jan 27;48(2):534-46.