Ro 90-7501

An antiviral useful in Alzheimer’s research

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库存: 现货

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5mg

￥1525.00

1220.00

- +
10mg

￥2900.00

2320.00

- +
25mg

￥6775.00

5420.00

- +
50mg

￥11900.00

9520.00

- +

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金额: ￥0.00

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货号: ajci5092
CAS: 293762-45-5
别名:
分子式: C20H16N6
分子量: 340.39
纯度: >98%
溶解度: 15 mg/ml in DMF, 10 mg/ml in DMSO, 2 mg/ml in Ethanol
储存: Store at -20°C
库存: 现货

Background

Ro 90-7501 is a bi-benzimidazole compound that was first found to retard the formation of mature amyloid β42 fibrils in a cell-based assay.[1] Instead, extended polymeric sheets and fibrillary intermediates of amyloid β42 accumulated in response to Ro 90-7501 treatment, resulting in reduced cytotoxicity (EC50 = 2 μM).1 More recently, Ro 90-7501 was shown to modulate signaling in cells stimulated with polyinosinic-polycytidylic acid (poly(I:C); a toll-like receptor 3 (TLR3), and RIG-1-like receptor agonist.[2] Ro 90-7501 (10 μM) enhanced poly(I:C)-induced IFN-β expression, decreased NF-κB activation, and amplified the suppression of vesiculastomatitis virus replication by poly(I:C) in HEK293 cells expressing TLR3.[2]

Reference
[1]. Bohrmann, B., Adrian, M., Dubochet, J., et al. Self-assembly ofβamyloid 42 is retarded by small molecular ligands at the stage of structural intermediates. Journal of Structural Biology 130(2-3), 232-246 (2000).
[2]. Guo, F., Mead, J., Aliya, N., et al. RO 90-7501 enhances TLR3 and RLR agonist induced antiviral response. PLoS One 7(10), (2012).