IKK-3 Inhibitor

A multi-kinase inhibitor

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库存: 现货

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数量
1mg

￥550.00

440.00

- +
5mg

￥2462.00

1970.00

- +
10mg

￥4337.00

3470.00

- +
50mg

￥18837.00

15070.00

- +

已选 0 种 0 瓶

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货号: ajci5426
CAS: 862812-98-4
别名: GSK 319347A
分子式: C22H19N3O5S2
分子量: 469.53
纯度: >98%
溶解度: DMF: 12.5 mg/ml,DMSO: 20 mg/ml,DMSO:PBS (7.2 pH) (1:3): 0.25 mg/ml
储存: Store at -20°C
库存: 现货

Background

An IKK-3 Inhibitor. The NF-κB/Rel transcription factors, known to be involved in the regulation of pro-inflammatory cytokines and the pathogenesis of a variety of diseases, are present in the cytosol in an inactive state, complexed with inhibitory IκB proteins. NF-κB is activated upon degradation of IκB following IKK-α and IKK-β phosphorylation. IKK-ε, a homolog of IKKα and IKK-β, can also activate NF-κB. IKK-ε is expressed predominantly in immune cells, and is thought to play a role in the immune response. It is a benzimidazole analog that selectively inhibits IKK-ε with an IC50 value of 40 nM and is essentially inactive at IKK-α and IKK-β.