7-Chlorokynurenic acid

A glycine-site selective NMDA receptor antagonist

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10mg

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货号: ajci5804
CAS: 18000-24-3
别名: 7-氯犬尿酸,7-CKA
分子式: C10H6ClNO3
分子量: 223.62
纯度: >98%
溶解度: DMSO: slightly soluble,Ethanol: slightly soluble
储存: Store at RT
库存: 现货

Background

7-Chloro-4-hydroxyquinoline-2-carboxylic acid (7-Chlorokynurenic acid) is a potent and selective antagonist of the glycine B coagonist site of the N-methyl-D-aspartate (NMDA) receptor (IC50=0.56 μM). 7-Chloro-4-hydroxyquinoline-2-carboxylic acid is also a potent inhibitor of the reuptake of glutamate into synaptic vesicles with a Ki of 0.59 μM. 7-Chloro-4-hydroxyquinoline-2-carboxylic acid has potent antinociceptive actions after neuraxial delivery[1][2].

Male Sprague-Dawley rats pretreated with 7-Chloro-4-hydroxyquinoline-2-carboxylic acid (10 nM) shows a significant retardation of development of both the electroencephalographic and motor (17.7±2.9 daily stimulations) components of the seizure response[3].

参考文献:
[1]. Kemp JA, et al. 7-Chlorokynurenic acid is a selective antagonist at the glycine modulatory site of the N-methyl-D-aspartate receptor complex. Proc Natl Acad Sci U S A. 1988 Sep;85(17):6547-50.
[2]. Yaksh TL, et al. Characterization of the Effects of L-4-Chlorokynurenine on Nociception in Rodents. J Pain. 2017 Oct;18(10):1184-1196.
[3]. Croucher MJ, et al. 7-Chlorokynurenic acid, a strychnine-insensitive glycine receptor antagonist, inhibits limbic seizurekindling. Neurosci Lett. 1990 Oct 2;118(1):29-32.