DHBP dibromide

DHBP 二溴化物是一种钙释放抑制剂和一种肌肉松弛剂。

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库存: 现货

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数量
100mg

￥550.00

440.00

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货号: ajci5814
CAS: 6159-05-3
别名: 二溴化-1,1ˊ-二庚基-4,4ˊ-联吡啶鎓,Diheptylviologen dibromide
分子式: C24H38Br2N2
分子量: 514.39
纯度: >98%
溶解度: Soluble to 100 mM in sterile water
储存: Store at RT
库存: 现货

Background

DHBP dibromide is an inhibitor for calcium release and a muscle relaxant.

DHBP inhibits the calcium release induced by 2 mM caffeine and 2 μg/mL polylysine with an IC50 value of 5 μg/mL and 4 μg/mL, respectively. DHBP inhibits [3H]-ryanodine binding in a dose-dependent manner with an IC50 of 2.5 μg/mL and 90-100% inhibition at 20-30 μg/mL. Calcium uptake by SR is inhibited in the presence of caffeine and this inhibition is antagonized by concomitant addition of DHBP. Muscle twitches elicited by direct electrical muscle stimulation and contractions induced by either 10 mM caffeine or 1 fLM ryanodine are blocked by pretreatment with DHBP. DHBP blocks the calcium release from SR by direct interaction with the calcium release channel, also known as the ryanodine receptor[1].

参考文献:
[1]. Kang JJ, et al. Effects of bipyridylium compounds on calcium release from triadic vesicles isolated from rabbit skeletal muscle. Br J Pharmacol. 1994 Aug;112(4):1216-22.