IQ 1

A stem cell pluripotency factor

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10mg

￥825.00

660.00

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50mg

￥2400.00

1920.00

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货号: ajci6062
CAS: 331001-62-8
别名:
分子式: C21H22N4O2
分子量: 362.42
纯度: >98%
溶解度: DMF: 30 mg/ml,DMSO: 25 mg/ml,Ethanol: 10 mg/ml
储存: Store at -20°C
库存: 现货

Background

IQ 1 has many functions such as decreasing Wnt-stimulated phosphorylation, maintaining the pluripotency of murine ESCs, preventing PP2A/Nkd interaction and so on.IQ 1 maintains the pluripotency of murine ESCs in long-term culture in a Wnt-dependent manner. IQ 1 decreased Wnt-stimulated phosphorylation of p300 at Ser-89.IQ-1 binds to serine/threonine phosphatase PP2A and prevents PP2A/Nkd interaction.The binding of IQ 1 to PR72/130 leads to decreased phosphorylation of the coactivator protein p300 at Ser-89. IQ 1 thereby diminishes the β-catenin/p300 interaction and prevents β-catenin coactivator switching from CBP to p300.

参考文献:
[1]. Miyabayashi T et al. Wnt/beta-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotency. Proc Natl Acad Sci U S A, 2007 Mar 27, 104(13):5668-73.