Varenicline Tartrate

An agonist of α7 and α4β2 nAChRs

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库存: 现货

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5mg

￥625.00

500.00

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25mg

￥1912.00

1530.00

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货号: ajci6138
CAS: 375815-87-5
别名: 酒石酸伐尼克兰; CP 526555-18
分子式: C13H13N3.C4H6O6
分子量: 361.35
纯度: >98%
溶解度: ≥ 18.07mg/mL in DMSO, ≥ 96.2 mg/mL in Water
储存: Store at -20°C
库存: 现货

Background

Varenicline Tartrate(CP 526555;Champix) is a nicotinic receptor partial agonist; it stimulates nicotine receptors more weakly than nicotine itself does.IC50 value:Target: α4β2 nAChRVarenicline(CP 526555; Champix; Chantix) is a prescription medication used to treat smoking addiction. As a partial agonist it both reduces cravings for and decreases the pleasurable effects of cigarettes and other tobacco products. Through these mechanisms Varenicline(CP 526555; Champix; Chantix) can assist some patients to quit smoking.

参考文献:
[1]. Krebs P, Sherman SE. Review: Varenicline for tobacco cessation does not increase CV serious adverse events. Ann Intern Med. 2012 Aug 21;157(4):JC2-2.
[2]. Kikkawa, H.; Maruyama, N.; Fujimoto, Y.; Hasunuma, T. Single- and multiple-dose pharmacokinetics of the selective nicotinic receptor partial agonist, varenicline, in healthy Japanese adult smokers.Journal of Clinical Pharmacology (2011), 51(4), 527-537.
[3]. Pachas GN, Cather C, Pratt SA et al. Varenicline for Smoking Cessation in Schizophrenia: Safety and Effectiveness in a 12-Week, Open-Label Trial. J Dual Diagn. 2012;8(2):117-125.
[4]. Bordia T, Hrachova M, Chin M et al. Varenicline Is a Potent Partial Agonist at α6β2* Nicotinic Acetylcholine Receptors in Rat and Monkey Striatum. J Pharmacol Exp Ther. 2012 Aug;342(2):327-34.
[5]. Varenicline