Jervine

An inhibitor of the hedgehog signaling pathway

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库存: 现货

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5mg

￥875.00

700.00

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10mg

￥1625.00

1300.00

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50mg

￥7387.00

5910.00

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100mg

￥12825.00

10260.00

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货号: ajci6464
CAS: 469-59-0
别名: 蒜黎芦碱; 11-Ketocyclopamine
分子式: C27H39NO3
分子量: 425.6
纯度: >98%
溶解度: DMF: 2 mg/ml,Ethanol: 10 mg/ml,Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/ml
储存: Store at -20°C
库存: 现货

Background

Jervine(11-Ketocyclopamine) is a naturally occuring steroidal alkaloid that causes cyclopia by blocking sonic hedgehog(Shh) signaling; Jervine is an inhibitor of Smo.IC50 value:Target: sonic hedgehog is derived from the Veratrum plant species. It is a close structural analog of cyclopamine which specifically inhibits the hedgehog (Hh) pathway by interaction with the hedgehog signaling protein Smo. Jervine can be used to induce abnormal morphogenesis in a number of experimental models. Jervine is an inhibitor of Smo.

参考文献:
[1]. Incardona JP, et al. Cyclopamine inhibition of Sonic hedgehog signal transduction is not mediated through effects on cholesterol transport. Dev Biol. 2000 Aug 15;224(2):440-52.
[2]. Chen JK, et al. Small molecule modulation of Smoothened activity. Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14071-6.
[3]. Mistretta CM, et al. Cyclopamine and jervine in embryonic rat tongue cultures demonstrate a role for Shh signaling in taste papilla development and patterning: fungiform papillae double in number and form in novel locations in dorsal lingual epithelium. Dev Biol. 2003 Feb 1;254(1):1-18.