SANT-2

A Smoothened receptor antagonist

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库存: 现货

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5mg

￥1212.00

970.00

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10mg

￥2337.00

1870.00

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25mg

￥5462.00

4370.00

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50mg

￥10337.00

8270.00

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货号: ajci6628
CAS: 329196-48-7
别名: N-[3-(1H-苯并咪唑-2-基)-4-氯苯基]-3,4,5-三乙氧基苯甲酰胺
分子式: C26H26ClN3O4
分子量: 479.96
纯度: >98%
溶解度: 30mg/mL in DMSO, or in DMF
储存: Store at -20°C
库存: 现货

Background

SANT-2 is a Smoothened (Smo) receptor antagonist.[1],[2] It binds to the Smo receptor (Kd = 12 nM) and inhibits binding of the Smo receptor agonist SAG-1.3 and antagonist cyclopamine(Kis = 7.8 and 8.4 nM, respectively). SANT-2 inhibits hedgehog signaling induced by an N-terminal fragment of sonic hedgehog (Shh) in an Shh-LIGHT2 cellular assay (IC50 = 30 nM).[1]

Reference:
[1]. Chen, J.K., Taipale, J., Young, K.E., et al. Small molecule modulation of smoothened activity. Proc. Natl. Acad. Sci. USA 99(22), 14071-14076 (2002).
[2]. Rominger, C.M., Bee, W.L.T., Copeland, R.A., et al. Evidence for allosteric interactions of antagonist binding to the smoothened receptor. J. Pharmacol. Exp. Ther. 329(3), 995-1005 (2009).