α-Zearalenol

A major hepatic metabolite of zearalenone

此产品仅用于科学研究，我们不为任何个人用途提供产品和服务

库存: 现货

可选规格

包装

价格

促销价

数量
1mg

￥1162.00

930.00

- +
5mg

￥3050.00

2440.00

- +
10mg

￥4525.00

3620.00

- +

已选 0 种 0 瓶

金额: ￥0.00

首页收藏

货号: ajci7710
CAS: 36455-72-8
别名: ALPHA-玉米赤霉烯醇
分子式: C18H24O5
分子量: 320.4
纯度: >98%
溶解度: ≤20mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide
储存: Store at -20°C
库存: 现货

Background

Zearalenone (ZEA) is a mycotoxin produced mainly by fungi in foods and feeds. It is frequently involved in reproductive disorders of farm animals and occasionally in hyperoestrogenic syndromes in humans. ZEA and its metabolites possess oestrogenic activity in cattle, pigs and sheep. However, oral or interperitoneal administration of ZEA is relatively low acute toxic in mice, rat and pig. ZEA transformed into two metabolites α-zearalenol (α-ZEA) and β-zearalenol (β-ZEA) in animals which are subsequently conjugated with glucuronic acid. Moreover, ZEA has also been shown to be hepatotoxic, haematotoxic, immunotoxic and genotoxic. α-Zearalenol is a major hepatic metabolite in rats of zearalenone which impacts mammalian reproduction and development [1].

In vitro: The binding characteristic of α-ZEA was less potent with estrogen receptors than the parent compound [2]. α-zearalenol showed pronounced effects on uterotropic activity [3]. α-ZEA inhibited normal sperm motility, but stimulated hyperactive motility in the remaining motile cells and simultaneously induced the acrosome reaction [4].

参考文献:
[1].? Zinedine A, Soriano J M, Molto J C, et al. Review on the toxicity, occurrence, metabolism, detoxification, regulations and intake of zearalenone: an oestrogenic mycotoxin[J]. Food and chemical toxicology, 2007, 45(1): 1-18.
[2].? Kiang D T, Kennedy B J, Pathre S V, et al. Binding characteristics of zearalenone analogs to estrogen receptors[J]. Cancer research, 1978, 38(11 Part 1): 3611-3615.
[3].? Mirocha C J, Pathre S V, Behrens J, et al. Uterotropic activity of cis and trans isomers of zearalenone and zearalenol[J]. Applied and environmental microbiology, 1978, 35(5): 986-987.
[4].? Filannino A, Stout T A E, Gadella B M, et al. Dose-response effects of estrogenic mycotoxins (zearalenone, alpha-and beta-zearalenol) on motility, hyperactivation and the acrosome reaction of stallion sperm[J]. Reproductive Biology and Endocrinology, 2011, 9(1): 134.