B-Raf inhibitor

B-Raf inhibitor 是一种有效的双重 TGFβ-activated kinase 1 (TAK1) 和 mitogen-activated protein kinase kinase kinase 2 (MAP4K2) 抑制剂，IC50 分别为 41.1 nM 和 18.2 nM。

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库存: 现货

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5mg

￥2637.00

2110.00

- +
10mg

￥3087.00

2470.00

- +
50mg

￥8825.00

7060.00

- +
200mg

￥18350.00

14680.00

- +

已选 0 种 0 瓶

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货号: ajci8544
CAS: 1315330-11-0
别名: N-[4-[(4-乙基-1-哌嗪基)甲基]-3-(三氟甲基)苯基]-4-甲基-3-[(6-甲基-7H-吡咯并[2,3-D]嘧啶-4-基)氧基]苯甲酰胺
分子式: C29H31F3N6O2
分子量: 552.59
纯度: >98%
溶解度: Soluble in DMSO
储存: Store at -20°C
库存: 现货

Background

TAK1/MAP4K2 inhibitor 1 is a potent dual TGFβ-activated kinase 1 (TAK1) and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2) inhibitor, with IC50s of 41.1 nM and 18.2 nM, respectively.

TAK1/MAP4K2 inhibitor 1 has moderate terminal elimination half-life (t1/2=2.94 h for mice (1 mg/kg, iv))[1].

参考文献:
[1]. Tan L, et al. Discovery of type II inhibitors of TGFβ-activated kinase 1 (TAK1) and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2). J Med Chem. 2015 Jan 8;58(1):183-96.