AN3365 (hydrochloride)

A LeuRS inhibitor

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库存: 现货

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5mg

￥1525.00

1220.00

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10mg

￥2500.00

2000.00

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25mg

￥5500.00

4400.00

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50mg

￥8850.00

7080.00

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100mg

￥14100.00

11280.00

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货号: ajci8932
CAS: 1234563-16-6
别名: 3-[[(3S)-3-(氨基甲基)-1,3-二氢-1-羟基-2,1-苯并氧杂硼戊环-7-基]氧基]-1-丙醇盐酸盐,Epetraborole,GSK2251052
分子式: C11H16BNO4 ? HCl
分子量: 273.5
纯度: >98%
溶解度: ≤10mg/ml in DMSO
储存: Store at -20°C
库存: 现货

Background

AN3365 is a potent and selective leucyl-tRNA synthetase inhibitor [1].

The leucyl-tRNA synthetase belongs to a member of the class I aminoacyl-tRNA synthetase family. The leucyl-tRNA synthetase has been involved in catalyzing the ATP-dependent ligation of L-leucine to tRNA. It has been found in the cytoplasm as part of a multisynthetase complex and interacts with the arginine tRNA synthetase through its C-terminal domain [2].

AN3365 potently and selectively inhibited bacterial leucyl-tRNA synthetase activity against Gram-negative bacteria. AN3365 was a member of a novel class of boron-containing compounds, the aminomethyl benzoxoaboroles, which showed potential to combat multidrug resistance. AN3365 was active against many microbial strains, including strains of Enterobacteriaceae with the MIC50/90 of 0.5/1 μg/ml. AN3365 showed activity against the non-fermentative Gram-negative clinical isolates P. aeruginosa, A. baumannii, S. maltophilia, and B. cepacid with the MIC50/90s of 4/8, 4/8, 2/4, and 8/32 μg/ml, respectively [1].

参考文献:
[1] Hernandez V, Crépin T, Palencia A, et al.? Discovery of a novel class of boron-based antibacterials with activity against gram-negative bacteria[J]. Antimicrobial agents and chemotherapy, 2013, 57(3): 1394-1403.
[2] Rouget P, Chapeville F.? Leucyl‐tRNA Synthetase[J]. European journal of biochemistry, 1971, 23(3): 443-451.