Eribulin mesylate

Eribulin mesylate (E7389 mesylate) 是一种微管靶向剂，用于研究转移性乳腺癌。甲磺酸艾日布林通过结合微管蛋白和微管来抑制癌细胞的增殖。

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库存: 现货

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500ug

￥6475.00

5180.00

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1mg

￥10362.00

8290.00

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货号: ajci9208
CAS: 441045-17-6
别名: 甲磺酸艾日布林; B1939 mesylate; E7389 mesylate; ER-086526 mesylate
分子式: C41H63NO14S
分子量: 826
纯度: >98%
溶解度: Soluble in DMSO
储存: Store at -20°C, protect from light, stored under nitrogen
库存: 现货

Background

Eribulin mesylate (E7389 mesylate) is a microtubule targeting agent that is used in the treatment of metastatic breast cancer. Eribulin mesylate (E7389 mesylate) inhibits the proliferation of cancer cells by binding microtubule proteins and microtubules.

参考文献:
[1]. Okouneva, T., et al., Inhibition of centromere dynamics by eribulin (E7389) during mitotic metaphase. Mol Cancer Ther, 2008. 7(7): p. 2003-11.
[2]. Smith, J.A., et al., Eribulin binds at microtubule ends to a single site on tubulin to suppress dynamic instability. Biochemistry, 2010. 49(6): p. 1331-7.
[3]. Towle, M.J., et al., Eribulin induces irreversible mitotic blockade: implications of cell-based pharmacodynamics for in vivo efficacy under intermittent dosing conditions. Cancer Res, 2011. 71(2): p. 496-505.