O4I1

An inducer of Oct3/4

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库存: 现货

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20mg

￥637.00

510.00

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50mg

￥1637.00

1310.00

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200mg

￥5175.00

4140.00

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货号: ajci9240
CAS: 175135-47-4
别名: 2-(4-[(4-甲氧基苄基)氧基]苯基)乙腈
分子式: C16H15NO2
分子量: 253.3
纯度: >98%
溶解度: DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2)(1:5): 0.16 mg/ml,Ethanol: slightly
储存: Store at -20°C
库存: 现货

Background

O4I1 is a potent Oct3/4 inducer implicated in promoting the expression and stabilization of Oct3/4. O4I1 can enhance the transcriptional activity of Oct3/4 in a variety of human somatic cells. Oct3/4, also known as POU5F1 and Oct4, is a transcription factor which is essential for self-renewal and pluripotency of embryonic stem cells. Oct3/4 is specifically expressed in the ES cells, epiblast, preimplantation embryos, and germ cells, et al [1].

When treated the synthesized cDNA from RNA isolated from the HEK293 cells with 10 μM and 20 μM O4I1 for 72 hrs, the Oct3/4 mRNA levels increased about 2.5- and 4-fold respectively. In human adult primary fibroblast (HF) and human neonatal foreskin fibroblast (HFF) cell lines, treatment with 10 μM O4I1 increased the gene and protein expression level of Oct3/4 after 72 hrs incubation in HF cells and 7 days in HFF cells. The derivatives of O4I1 such as compound 2, showed a time-dependent activation of Oct3/4 and markedly elevated the efficiency of Oct3/4 induction [1].

Reference:
[1].Cheng X, Dimou E, Alborzinia H, et al.? Identification of 2-[4-[(4-Methoxyphenyl) methoxy]-phenyl] acetonitrile and Derivatives as Potent Oct3/4 Inducers[J]. Journal of medicinal chemistry, 2015, 58(12): 4976-4983.