NS309

A Ca2+-activated IK/SK potassium channel activator

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库存: 现货

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5mg

￥437.00

350.00

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50mg

￥2112.00

1690.00

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货号: ajci9298
CAS: 18711-16-5
别名: 3-肟-6,7-二氯-1H-吲哚-2,3-二酮,NS 309;NS-309
分子式: C8H4Cl2N2O2
分子量: 231.04
纯度: >98%
溶解度: Soluble in DMSO
储存: Store at -20°C
库存: 现货

Background

NS309 is a positive modulator of small- and intermediate- conductance Ca2+-activated K+ channels (KCa2 and KCa3.1 channels); increases Ca2+ sensitivity. Displays no activity at BK channels.IC50 value: Ca2+-activated K+ channelTarget:

参考文献:
[1]. Stankevicius, Edgaras; Dalsgaard, Thomas; Kroigaard, Christel et al. Opening of small and intermediate calcium-activated potassium channels induces relaxation mainly mediated by nitric-oxide release in large arteries and endothelium-derived hyperpolarizin
[2]. Seear, Rachel V.; Lew, Virgilio L. IKCa agonist (NS309)-elicited all-or-none dehydration response of human red blood cells is cell-age dependent. Cell Calcium (2011), 50(5), 444-448.
[3]. Dalsgaard, T.; Kroigaard, C.; Misfeldt, M. Openers of small conductance calcium-activated potassium channels selectively enhance NO-mediated bradykinin vasodilatation in porcine retinal arterioles. British Journal of Pharmacology (2010), 160(6), 1496-1508
[4]. Broendum, E.; Kold-Petersen, H.; Simonsen, U.; Aalkjaer, C. NS309 restores EDHF-type relaxation in mesenteric small arteries from type 2 diabetic ZDF rats. British Journal of Pharmacology (2010), 159(1), 154-165.