Bilobalide

A neuroprotective natural product

此产品仅用于科学研究，我们不为任何个人用途提供产品和服务

库存: 现货

可选规格

包装

价格

促销价

数量
25mg

￥412.00

330.00

- +
50mg

￥825.00

660.00

- +
100mg

￥1487.00

1190.00

- +

已选 0 种 0 瓶

金额: ￥0.00

首页收藏

货号: ajci9324
CAS: 33570-04-6
别名: 白果内酯; (-)-Bilobalide
分子式: C15H18O8
分子量: 326.3
纯度: >98%
溶解度: ≥ 16.3 mg/mL in DMSO, ≥ 98.2 mg/mL in EtOH with gentle warming
储存: Store at -20°C
库存: 现货

Background

Description: IC50 Value: 3.33 (pIC50 Value) [1] Bilobalide is a biologically active terpenic trilactone present in Ginkgo biloba. An increasing number of studies have demonstrated its neuroprotective effects. in vitro: Inhibition by BB and GB was abolished in mutant receptors containing T6'S and S12'A substitutions, but their potencies were enhanced (42- and 125-fold, respectively) in S2'A mutant receptors [1]. BB enhanced the secretion of α-secretase-cleaved soluble amyloid precursor protein (sAPPα, a by-product of non-amyloidogenic processing of APP) and decreased the β amyloid protein (Aβ, a by-product of amyloidogenic processing of APP) via PI3K-dependent pathway [2]. in vivo: Oral administration of bilobalide (10-30 mg/kg) significantly inhibited thermal hyperalgesia in response to carrageenan, capsaicin and paw incision, independent of dose, with an efficacy similar to that of diclofenac. In the carrageenan model, mechanical hypersensitivity and paw oedema were also significantly reduced after treatment with bilobalide (10-30 mg/kg) [3]. BB(4 and 8 mg/kg) significantly protected VD rats against cognitive deficits in the Morris water maze. Biochemical assessment showed that BB (4 and 8 mg/kg) increased superoxide dismutase (SOD) activity and glutathione (GSH) content, and decreased nitric oxide synthase (NOS) activity and malondialdehyde (MDA) content [4]. Clinical trial: N/A