Kisspeptin 10 (human)

A potent agonist of GPR54

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1mg

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货号: ajci9358
CAS: 374675-21-5
别名: 亲吻促动素-10(人源)
分子式: C63H83N17O14
分子量: 1302.45
纯度: >98%
溶解度: DMF: 15 mg/ml,DMSO: 15 mg/ml,DMSO:PBS(pH 7.2) (1:2): 0.33 mg/ml
储存: Desiccate at -20°C
库存: 现货

Background

Kisspeptin-10, human is a potent vasoconstrictor and inhibitor of angiogenesis. Kisspeptin-10, human acts as a tumor metastasis suppressor via its receptor GPR54. Kisspeptin-10-GPR54 system plays an important role in embryonic kidney development. Kisspeptin-10/GPR54 signaling induces osteoblast differentiation via NFATc4-mediated BMP2 expression[1].
Kisspeptin-10 (KP-10) and its receptor GPR54 are key components in the regulation of GnRH secretion in humans and other mammals. Kisspeptin-10 protein binds to GPR54. Activation of Kisspeptin-10 suppresses pulmonary human melanoma and Kisspeptin-10 is a metastasis suppressor in breast cancer cells[1].
Reference: [1]. Son HE, et al. Kisspeptin-10 (KP-10) stimulates osteoblast differentiation through GPR54-mediated regulation of BMP2 expression and activation. Sci Rep. 2018 Feb 1;8(1):2134.