Ryanodine

Ryanodine 是一种细胞渗透性的ryanodine 受体调节剂。

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库存: 现货

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1mg

￥4662.00

3730.00

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货号: ajci9456
CAS: 15662-33-6
别名: 利阿诺定
分子式: C25H35NO9
分子量: 493.55
纯度: >98%
溶解度: <12.34mg/ml in DMSO; <4.94mg/ml in ethanol
储存: Desiccate at -20°C
库存: 现货

Background

Ryanodine is a cell permeant ryanodine receptor modulator. Ryanodine can either stimulate or inhibit Ryanodine-mediated Ca2+ release depending on its concentrations. Poisonous diterpenoid found in Ryania speciosa.

Ryanodine (100-5000 nM, 30-120 mintutes) irreversibly depresses twitch and tetanic tension of both fast and slow muscle in a dose-related manner[1]. At concentrations above 250 nM, ryanodine induces a slowly developing, dose dependent contracture which could not be blocked by 5 mMCo2+[1].

参考文献:
[1]. Meissner G, et al. Ryanodine activation and inhibition of the Ca2+ release channel of sarcoplasmic reticulum. J Biol Chem. 1986 May 15;261(14):6300-6.
[2]. Fryer MW, et al. The action of ryanodine on rat fast and slow intact skeletal muscles. J Physiol. 1989 Jul;414:399-413.