NKH 477

Water-soluble analog of forskolin

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库存: 现货

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1mg

￥312.00

250.00

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5mg

￥1100.00

880.00

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10mg

￥1962.00

1570.00

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货号: ajci9522
CAS: 138605-00-2
别名: Colforsin dapropate hydrochloride
分子式: C27H43NO8.HCl
分子量: 546.1
纯度: >98%
溶解度: DMF: 20 mg/ml,DMSO: 30 mg/ml,DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml,Ethanol: 2.5 mg/ml
储存: Store at -20°C,unstable in solution, ready to use.
库存: 现货

Background

NKH477 (Colforsin dapropate hydrochloride) is a novel water-soluble forskolin derivative that improves cardiac failure mainly through its beneficial effects on diastolic cardiac function. NKH477 directly activates the catalytic unit of adenylate cyclase and increases intracellular cAMP. NKH477 exerts an antiproliferative effect in vivo with an altered cytokine profile to inhibit the acute rejection of rat orthotopic lung allografts[1].

NKH477 (Colforsin dapropate hydrochloride) (orally; 1-3 mg/kg/day; days 3 and 5) prolonged lung allograft survival in a dose dependent manner[1].

参考文献:
[1]. Nakashima S, et al. Antiproliferative effects of NKH477, a forskolin derivative, on cytokine profile in rat lung allografts. J Heart Lung Transplant. 2005 Apr;24(4):462-9.