Mastoparan

A mast cell degranulating peptide

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库存: 现货

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1mg

￥1087.00

870.00

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5mg

￥4250.00

3400.00

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10mg

￥6687.00

5350.00

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25mg

￥12825.00

10260.00

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货号: ajci9626
CAS: 72093-21-1
别名: 黄峰毒素
分子式: C70H131N19O15
分子量: 1479
纯度: >98%
溶解度: Soluble to 2.60 mg/ml in sterile water
储存: Desiccate at -20°C
库存: 现货

Background

Mastoparan, a tetradecapeptide which is a component of wasp venom, stimulates release of prolactin from cultured rat anterior pituitary cells.

Mastoparan has an amphiphilic nature and is reported to exert a variety of pharmacological and biochemical effects. Mastoparan induces exocytosis of hormones from anterior pituitary cells. Mastoparan stimulation of prolactin secretion is dose-dependent, time-dependent, reversible and required the presence of calcium. Mastoparan causes translocation of protein kinase C activity from a soluble to a membrane-attached form. Mastoparan is able to increase the intracellular Ca2+ concentration in Fura-2-loaded individual lactotrophs. Mastoparan is also able to interact with GTP-bindmg proteins. Thus, Mastoparan has been shown to facilitate exchange of nucleotides and to stimulate GTPase activity on G-proteins. It has therefore been proposed that the cellular effects of Mastoparan are due to an ability to mimic G-protein-linked agonist-liganded receptors[1].

参考文献:
[1]. Mau SE, et al. Mastoparan, a wasp venom peptide, stimulates release of prolactin from cultured rat anterior pituitary cells. J Endocrinol. 1994 Jul;142(1):9-18.