[Pyr1]-Apelin-13

[Pyr1]-Apelin-13 是一种高效的选择性内源性 apelin 受体 (APJ) 激动剂。

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库存: 现货

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1mg

￥937.00

750.00

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5mg

￥3687.00

2950.00

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10mg

￥6912.00

5530.00

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货号: ajci9732
CAS: 217082-60-5
别名: 人牛吡啶APELIN-13,[pGlu1]-Apelin-13
分子式: C69H108N22O16S
分子量: 1533.81
纯度: >98%
溶解度: Soluble to 1 mg/ml in sterile water
储存: Desiccate at -20°C
库存: 现货

Background

[Pyr1]-Apelin-13 is a highly potent, selective endogenous apelin receptor (APJ) agonist.

[Pyr1]-apelin-13 encapsulation in lipoPEG particles (lipoPEG-PA13) results in sustained and extended drug release under physiological conditions[1].

[Pyr1]-apelin-13 nanocarriers in a mouse model of pressure-overload induced heart failure demonstrate a sustainable long-term effect of [Pyr1]-apelin-13 in preventing cardiac dysfunction[1]. [Pyr1] apelin-13 (1, 5 μg) improves locomotor activity and reduces pain symptoms, cavity size and caspase-3 levels in rats. [Pyr1] apelin-13 (1, 5 μg) significantly increases thermal paw withdrawal latency. [Pyr1] apelin-13 in 5 μg dose also produces significant attenuation in paw withdrawal threshold compared to SCI animals from the second week post SCI[2].

参考文献:
[1]. Serpooshan V, et al. [Pyr1]-Apelin-13 delivery via nano-liposomal encapsulation attenuates pressure overload-induced cardiac dysfunction. Biomaterials. 2015 Jan;37:289-98.
[2]. Hajimashhadi Z, et al. Chronic administration of [Pyr1] apelin-13 attenuates neuropathic pain after compression spinal cord injury in rats. Neuropeptides. 2017 Feb;61:15-22.