Dibutyryl-cAMP, sodium salt

A cell-permeable, cAMP analog

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50mg

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货号: ajci9890
CAS: 16980-89-5
别名: Dibutyryl cAMP sodium salt; DBcAMP sodium salt
分子式: C18H23N5NaO8P
分子量: 491.37
纯度: >98%
溶解度: ≥ 49.1mg/mL in Water
储存: Store at -20°C
库存: 现货

Background

Bucladesine sodium salt (Dibutyryl-cAMP sodium salt; DC2797; Sodium dibutyryl cAMP) is a cell-permeable cyclic AMP (cAMP) analog that activates cAMP dependent protein kinase (PKA) by increasing the intracellular level of cAMP. Bucladesine sodium salt acts as a phosphodiesterase (PDE) inhibitor.

参考文献:
[1]. Sharifzadeh, M., et al., Post-training intrahippocampal infusion of nicotine-bucladesine combination causes a synergistic enhancement effect on spatial memory retention in rats. Eur J Pharmacol, 2007. 562(3): p. 212-20.
[2]. Azami, K., et al., The quantitative evaluation of cholinergic markers in spatial memory improvement induced by nicotine-bucladesine combination in rats. Eur J Pharmacol, 2010. 636(1-3): p. 102-7.
[3]. Mafune, E., M. Takahashi, and N. Takasugi, Effect of vehicles on percutaneous absorption of bucladesine (dibutyryl cyclic AMP) in normal and damaged rat skin. Biol Pharm Bull, 1995. 18(11): p. 1539-43.
[4]. Rundfeldt, C., et al., The stable cyclic adenosine monophosphate analogue, dibutyryl cyclo-adenosine monophosphate (bucladesine), is active in a model of acute skin inflammation. Arch Dermatol Res, 2012.
[5]. Salehi F, et al. Effect of bucladesine, pentoxifylline, and H-89 as cyclic adenosine monophosphate analog, phosphodiesterase, and protein kinase A inhibitor on acute pain. Fundam Clin Pharmacol. 2017 Aug;31(4):411-419.