Atazanavir

An inhibitor of HIV-1 protease

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库存: 现货

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5mg

￥0.00

0.00

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10mg

￥762.00

610.00

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25mg

￥0.00

0.00

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50mg

￥2287.00

1830.00

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货号: ajci10132
CAS: 198904-31-3
别名: 阿扎那韦; BMS-232632
分子式: C38H52N6O7
分子量: 704.9
纯度: >98%
溶解度: ≥ 28.6mg/mL in DMSO, ≥ 9.9 mg/mL in EtOH with ultrasonic
储存: Store at -20°C
库存: 现货

Background

Atazanavir is a novel and potent azapeptide protease inhibitor that specifically inhibits the human immunodeficiency virus type 1 (HIV-1) protease enzyme with inhibition constant K_i of 66 nmol/L and also inhibits the viral replication of HIV-1 with 50% effective concentration EC₅₀ ranging from 2.6 to 5.3 nmol/L. Atazanavir binds to HIV-1 protease preventing the cleavage of gag and gag-pol polyproteins, which results in the formation of immature virions in HIV-1-infected cells. Atazanavir has a different C-2 symmetric chemical structure and a generally greater antiretroviral potency in various HIV strains compared to other protease inhibitors, including indinavir, nelfinavir, ritonavir, saquinavir and amprenavir.

Reference

[1].Fuster D, Clotet B. Review of atazanavir: a novel HIV protease inhibitor. Expert Opin Pharmacother. 2005 Aug;6(9):1565-72.
[2].Croom KF, Dhillon S, Keam SJ. Atazanavir: a review of its use in the management of HIV-1 infection. Drugs. 2009 May 29;69(8):1107-40. doi: 10.2165/00003495-200969080-00009.