UCL 2077

UCL 2077 是一种选择性慢后超极化 (sAHP) 通道阻滞剂（在培养的海马神经元中 IC50 =500 nM），对超极化后的 Ca2+ 通道、动作电位、输入电阻和介质影响最小。

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库存: 现货

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10mg

￥2650.00

2120.00

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50mg

￥10912.00

8730.00

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货号: ajci10618
CAS: 918311-87-2
别名:
分子式: C25H22N2
分子量: 350.46
纯度: >98%
溶解度: <17.52mg/ml in DMSO; <8.76mg/ml in ethanol
储存: Store at RT
库存: 现货

Background

UCL 2077 is a selective slow-afterhyperpolarization (sAHP) channel blocker (IC50 = 500 nM in hippocampal neurons in culture), having minimal effects on Ca2+ channels, action potentials, input resistance and the medium after hyperpolarization[1]. UCL 2077 is also a subtype-selective blocker of the epilepsy associated KCNQ channels[2].

参考文献:
[1]. Shah MM, et al. Enhancement of hippocampal pyramidal cell excitability by the novel selective slow-afterhyperpolarization channel blocker 3-(triphenylmethylaminomethyl)pyridine (UCL2077). Mol Pharmacol. 2006 Nov;70(5):1494-502.
[2]. Soh H, et al. The specific slow afterhyperpolarization inhibitor UCL2077 is a subtype-selective blocker of the epilepsy associated KCNQ channels. Mol Pharmacol. 2010 Dec;78(6):1088-95.