Ralfinamide mesylate

Ralfinamide mesylate (FCE-26742A mesylate) 是一种来自 α-氨基酰胺的口服 Na+ 通道阻滞剂，具有抑制疼痛的作用。

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库存: 现货

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10mg

￥987.00

790.00

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50mg

￥3887.00

3110.00

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货号: ajci10808
CAS: 202825-45-4
别名: (S)-2-((4-((2-氟苄基)氧基)苄基)-氨基)丙酰胺甲烷磺酸酯,FCE-26742A mesylate
分子式: C17H19FN2O2.CH3SO3H
分子量: 398.45
纯度: >98%
溶解度: <9.96mg/ml in Water; <39.84mg/ml in DMSO
储存: Store at -20°C
库存: 现货

Background

Ralfinamide mesylate (FCE-26742A mesylate) is an orally available Na+ channel blocker derived from α-aminoamide, with function of suppressing pain[1][2].

Ralfinamide (30 mg/kg, 60 mg/kg; p.o.; twice daily; 42 days) treated with Ralfinamide (80 mg/kg; p.o.; twice daily; 7 days) preoperatively suppresses neuropathic pain[1].

参考文献:
[1]. Zhang SH, et al. Ralfinamide administered orally before hindpaw neurectomy or postoperatively provided long-lasting suppression of spontaneous neuropathic pain-related behavior in the rat. Pain. 2008 Oct 15;139(2):293-305.
[2]. Liang X, et al. Effects of ralfinamide in models of nerve injury and chemotherapy-induced neuropathic pain. Eur J Pharmacol. 2018 Mar 15;823:27-34.