Ac-VDVAD-AFC

A fluorogenic substrate for caspase-2

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1mg

￥1275.00

1020.00

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5mg

￥3487.00

2790.00

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10mg

￥6275.00

5020.00

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货号: ajci11042
CAS: 210344-94-8
别名: N-Acetyl-Val-Asp-Val-Ala-Asp-7-amino-4-Trifluoromethylcoumarin Caspase-2 Substrate (Fluorogenic)
分子式: C33H41F3N6O12
分子量: 770.71
纯度: >98%
溶解度: DMF: 10 mg/ml,DMSO: 10 mg/ml
储存: Store at -20°C
库存: 现货

Background

Ac-VDVAD-AFC is a fluorogenic substrate whose amino acids VDVAD have been shown to be a preferred cleavage site for caspase-2.1,2?Caspase activity can be quantified by fluorescent detection of free AFC (also known as 7-amino-4-trifluoromethylcoumarin), which is excited at 400 nm and emits at 505 nm. Increases in Ac-VDVAD-AFC cleavage have been reported to correlate with nitric oxide-induced activation of caspase-2 and subsequent apoptosis in human neuroblastoma lines.1

Product Description 参考文献
1. Moriya, R., Uehara, T., and Nomura, Y. Mechanism of nitric oxide-induced apoptosis in human neuroblastoma SH-SY5Y cells. FEBS Lett. 484(3), 253-260 (2000).

2. Talanian, R.V., Quinlan, C., Trautz, S., et al. Substrate specificities of caspase family proteases. The Journal of Biological Chemisty 272(15), 9677-9682 (1997).