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  • CP-640186
CP-640186的可视化放大

CP-640186

An ACC inhibitor

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CP-640186的二维码
  • 库存: 现货
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  • 1mg
    ¥1487.00
    1190.00
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  • 货号: ajci11110
  • CAS: 591778-68-6
  • 别名:
  • 分子式: C30H35N3O3
  • 分子量: 485.62
  • 纯度: >98%
  • 溶解度: ≥ 19.95mg/mL in DMSO
  • 储存: Store at -20°C
  • 库存: 现货

Background

CP-640186 is a potent and cell-permeable Acetyl-CoA carboxylase (ACC) inhibitor with IC50s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively.


参考文献:
[1]. Harwood HJ Jr, et al. Isozyme-nonselective N-substituted bipiperidylcarboxamide acetyl-CoA carboxylase inhibitors reduce tissue malonyl-CoA concentrations, inhibit fatty acid synthesis, and increase fatty acid oxidation in cultured cells and in experimental animals. J Biol Chem. 2003 Sep 26;278(39):37099-111.
[2]. Yamashita T, et al. Design, synthesis, and structure-activity relationships of spirolactones bearing 2-ureidobenzothiophene as acetyl-CoA carboxylases inhibitors. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6314-8.

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