安捷凯生物医药
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  • CNX-774
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CNX-774

A potent, selective, and irreversible BTK inhibitor

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CNX-774的二维码
  • 库存: 现货
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  • 包装
    价格
    促销价
    数量
  • 10mg
    ￥1737.00
    1390.00
    - +
  • 50mg
    ￥5212.00
    4170.00
    - +
已选 0 种 0 瓶
金额: ￥0.00
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使用我司产品发表的文章

  • 货号: ajci11120
  • CAS: 1202759-32-7
  • 别名:
  • 分子式: C26H22FN7O3
  • 分子量: 499.5
  • 纯度: >98%
  • 溶解度: DMF: 30 mg/ml,DMF:PBS(pH 7.2)(1:6): 0.14 mg/ml,DMSO: 25 mg/ml
  • 储存: Store at -20° C
  • 库存: 现货

Background

CNX-774 is an orally active and selective inhibitor of BTK with IC50 value of <1 nM.


Bruton’s tyrosine kinase (BTK) is an important enzyme in the B-cell antigen receptor (BCR) signaling pathway and also plays an important role in mast cell activation and B cell maturation.


CNX-774 is an orally active, irreversible and selective BTK inhibitor with IC50 value of <1 nM. CNX-774 formed covalent bond with the Cys481 residue within the ATP binding site of BTK. In cellular assays, CNX-774 inhibited BTK with IC50 values of 1-10 nM [1].

Reference:
[1].? Akinleye A, Chen Y, Mukhi N, et al. Ibrutinib and novel BTK inhibitors in clinical development. J Hematol Oncol, 2013, 6: 59.

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