PA-824

A anti-tuberculosis agent

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库存: 现货

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数量
5mg

￥537.00

430.00

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25mg

￥1200.00

960.00

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100mg

￥2787.00

2230.00

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500mg

￥10825.00

8660.00

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1g

￥20687.00

16550.00

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货号: ajci11364
CAS: 187235-37-6
别名: (S)-6,7-二氢-2-硝基-6-[[4-(三氟甲氧基)苯基]甲氧基]-5H-咪唑并[2,1-B][1,3]恶嗪,Pretomanid
分子式: C14H12F3N3O5
分子量: 359.26
纯度: >98%
溶解度: ≥ 17.85mg/mL in DMSO
储存: Store at -20°C
库存: 现货

Background

PA-824, a bicyclic nitroimidazoles, is an anti-tuberculosis (TB) agent that exerts potent in vitro activity against Mycobacterium tuberculosis with the minimal inhibition concentration (MIC) ranging from 0.015 μg/ml to 0.25 μg/ml and remains actively against a wide range of isolates that are resistant to commonly used anti-TB agents leading to its successful application in the treatment of TB [1].

PA-824 has been found to exhibit bactericidal activity against replicating bacilli and non-replicating bacilli under hypoxic or prolonged culture conditions in a dose dependent fashion through two possible mechanisms, which include PA-824 induced inhibition of ketomycolate synthesis and PA-824 mediated donation of nitric oxide during enzymatic nitro-reduction [1].

参考文献:
[1] Ahmad Z, Peloquin CA, Singh RP, Derendorf H, Tyagi S, Ginsberg A, Grosset JH, Nuermberger EL. PA-824 exhibits time-dependent activity in a murine model of tuberculosis. Antimicrob Agents Chemother. 2011 Jan;55(1):239-45. doi: 10.1128/AAC.00849-10. Epub 2010 Oct 11.