Doxycycline HCl

Doxycycline HCl 是一种抗生素，是一种具有口服活性的广谱金属蛋白酶 (MMP) 抑制剂。

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50mg

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货号: ajci11742
CAS: 10592-13-9
别名: 盐酸多西环素
分子式: C22H24N2O8.HCl
分子量: 480.9
纯度: >98%
溶解度: ≥ 16.4 mg/mL in DMSO, ≥ 48.5 mg/mL in Water, ≥ 9.7 mg/mL in EtOH with ultrasonic and warming
储存: Store at -20°C
库存: 现货

Background

Doxycycline hydrochloride, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor[1].

Doxycycline hydrochloride affects growth of glioma cells only under high concentrations[2]. Doxycycline hydrochloride decreases MT-CO1 protein content with concentrations of 1 μg/mL and higher in SVG cells[2].

Doxycycline hydrochloride (oral; 200 or 800 mg/kg/day; for 3 months) reduces active MMP-9 in untreated HT mice in a dose-dependent manner[1]

参考文献:
[1]. Wilfried Briest, et al. Doxycycline ameliorates the susceptibility to aortic lesions in a mouse model for the vascular type of Ehlers-Danlos syndrome. J Pharmacol Exp Ther. 2011 Jun;337(3):621-7.
[2]. Luger AL, et al. Doxycycline Impairs Mitochondrial Function and Protects Human Glioma Cells from Hypoxia-Induced Cell Death: Implications of Using Tet-Inducible Systems. Int J Mol Sci. 2018 May 17;19(5).