Alogliptin Benzoate

A DPP-4 inhibitor

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库存: 现货

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5mg

￥550.00

440.00

- +
10mg

￥925.00

740.00

- +
50mg

￥2987.00

2390.00

- +
100mg

￥3912.00

3130.00

- +

已选 0 种 0 瓶

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货号: ajci12140
CAS: 850649-62-6
别名: 苯甲酸阿格列汀; SYR 322
分子式: C25H27N5O4
分子量: 461.51
纯度: >98%
溶解度: ≥ 46.2 mg/mL in DMSO, ≥ 3.02 mg/mL in EtOH with ultrasonic and warming, ≥ 46.2 mg/mL in Water with gentle warming
储存: Store at -20°C
库存: 现货

Background

Alogliptin is a novel, highly selective and potent inhibitor of serine protease dipeptidylpeptidase-4 (DPP-4) with IC50 value of less than 10 nM [1].

Alogliptin has been reported to significantly reduce plasma DPP-4 activity and increase active GLP-1 levels in a dose-dependent manner in ob/ob?mice. Besides, alogliptin after 4?weeks administration remarkably reduced non-fasting glycosylated hemoglobin, non-fasting plasma glucose and triglyceride levels, as well as siginificantly increased non-fasting plasma insulin and fasting pancreatic insulin content in ob/ob?mice. Moreover, alogliptin treated ob/ob?mice have shown the increase of early-phase insulin secretion and the decrease of plasma glucose AUC [2]

参考文献:
[1] Feng J,?Zhang Z,?Wallace MB,?Stafford JA,?Kaldor SW,?Kassel DB,?Navre M,?Shi L,?Skene RJ,?Asakawa T,?Takeuchi K,?Xu R,?Webb DR,?Gwaltney SL 2nd. Discovery?of?alogliptin: a?potent,?selective,?bioavailable, and?efficacious?inhibitor?of?dipeptidyl?peptidase?IV. J Med Chem.?2007 May 17;50(10):2297-300.
[2] Moritoh Y1,?Takeuchi K,?Asakawa T,?Kataoka O,?Odaka H. Chronic administration of alogliptin, a novel, potent, and highly selective dipeptidyl peptidase-4 inhibitor, improves glycemic control and beta-cell function in obese diabetic ob/ob mice. Eur J Pharmacol.?2008 Jul 7;588(2-3):325-32.