Y 11

An inhibitor of FAK1

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1mg

￥737.00

590.00

- +
5mg

￥1475.00

1180.00

- +
10mg

￥2562.00

2050.00

- +
25mg

￥5412.00

4330.00

- +

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Background

Focal adhesion kinases (FAKs) are non-receptor tyrosine kinases that play roles in regulating diverse processes, including cell adhesion, spreading, migration, proliferation, and apoptosis. They are over-expressed in many types of cancer. Y11 inhibits FAK1 autophosphorylation by blocking phosphorylation of Y397.[1] At 100 μM, it was shown to decrease cell viability of T47D breast cancer and C8161 melanoma cell lines.[1]

Reference:
[1]. Golubovskaya, V.M., Nyberg, C., Zheng, M., et al. A small molecule inhibitor, 1,2,4,5-benzenetetraamine tetrahydrochloride, targeting the Y397 site of focal adhesion kinase decreases tumor growth. J. Med. Chem. 51(23), 7405-7416 (2008).