7ACC2

An MCT1 and MPC inhibitor

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库存: 现货

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包装

价格

促销价

数量
5mg

￥987.00

790.00

- +
10mg

￥1625.00

1300.00

- +
50mg

￥5512.00

4410.00

- +
100mg

￥8850.00

7080.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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货号: ajci13526
CAS: 1472624-85-3
别名:
分子式: C18H15NO4
分子量: 309.32
纯度: >98%
溶解度: DMF: 20 mg/ml,DMSO: 20 mg/ml,Ethanol: 0.5 mg/ml
储存: 4°C, protect from light
库存: 现货

Background

7ACC2 is a new potent MCT inhibitor with IC50 of 11 nM for inhibition of [14C]-lactate influx; new antitumor treatment targeting lactate transport in cancer cells.IC50 value: 11 nM ([14C]-lactate influx) [1]Target: MCT inhibitor; lactate transport inhibitor7ACC2 did not influence the prothrombin time which, together with a good in vitro ADME profile, supports the potential of this new family of compounds to act as anticancer drugs through inhibition of lactate flux.

参考文献:
[1]. Draoui N, et al. Synthesis and pharmacological evaluation of carboxycoumarins as a new antitumor treatment targeting lactate transport in cancer cells. Bioorg Med Chem. 2013 Nov 15;21(22):7107-17.