AH 6809

An EP and DP receptor antagonist

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库存: 现货

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5mg

￥875.00

700.00

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10mg

￥1525.00

1220.00

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50mg

￥5287.00

4230.00

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100mg

￥9500.00

7600.00

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货号: ajci14000
CAS: 33458-93-4
别名: 6-异丙氧基-9-氧代氧杂蒽-2-羧酸,AH6809;AH-6809
分子式: C17H14O5
分子量: 298.29
纯度: >98%
溶解度: 0.1 M Na2CO3: 4 mg/ml,DMF: 8 mg/ml,DMSO: 1 mg/ml,Ethanol: .5 mg/ml,PBS (pH 7.2): 0.34 mg/ml
储存: Store at -20°C
库存: 现货

Background

AH 6809 is an antagonist of prostaglandin receptor EP1, EP2 and D2 [1].

In COS-7 cells transfected with human EP2 receptor, AH 6809 treatment selectively inhibited the cAMP production increased by PGE2 but not forskolin. In the non-small cell lung cancer NCI-H1299 cell line, AH 6809 inhibited the binding of ³H-PGE2 to the cell membrane with IC50 value of 5 μM. The compound also inhibited the increase in cAMP level caused by PGE2 in NCI-H1299 cells. Moreover, AH 6809 significantly suppressed the cell proliferation and colony formation at low micromolar concentration. Besides that, AH 6809 exerted to be a specific DP-receptor blocking drug. It inhibited the anti-aggregation activity of PGD2 in whole blood [1, 2 and 3].

参考文献:
1.?Woodward D F, Pepperl D J, Burkey T H, et al. 6-isopropoxy-9-oxoxanthene-2-carboxylic acid (AH 6809), a human EP2receptor antagonist. Biochemical pharmacology, 1995, 50(10): 1731-1733.
2.?Qian X, Zhang J, Liu J. Tumor-secreted PGE2 inhibits CCL5 production in activated macrophages through cAMP/PKA signaling pathway. Journal of Biological Chemistry, 2011, 286(3): 2111-2120.
3.?Ito S, Okuda E, Sugama K, et al. Evaluation of ZK110841 and AH6809, an agonist and an antagonist of prostaglandin DP-receptors on human platelets, with a PGD2-responsive cell line from bovine embryonic trachea. British journal of pharmacology, 1990, 99(1): 13-14.