1-oleoyl-2-hydroxy-sn-glycero-3-phosphate (sodium salt)

1-油酰赖氨酸磷脂酸（LPA）是一种天然存在的磷脂质，具有多种效应。

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货号: ajci14522
CAS: 325465-93-8
别名: Oleoyl-sn-3-glycerophosphate
分子式: C21H40NaO7P
分子量: 458.5
纯度: >98%
溶解度: DMF: <50 μg/ml, DMSO: <50 μg/ml, EtOH: <50 μg/ml, PBS, pH 7.2: >8.3 mg/ml
储存: Store at -20°C
库存: 现货

Background

1-Oleoyl lysophosphatidic acid (LPA) is a naturally occurring phospholipid with various effects. LPA is widely distributed in many tissues. Similar to many other biomediators, LPA interacts with cells via specific cell surface receptors, such as G proteincoupled receptors, to induce biological effects.

In vitro: LPA could mediate signal transduction via Edg/LPA receptor, inducing the proliferation, migration, adhesion and antiapoptotic function of tumor cells. Additionally, LPA was found to elicit upregulation of VEGF, leading to an indirect influence on initiation and progression of malignancies. LPA could also stimulate matrix metalloproteinase secretion and tumor angiogenesis factor [1].

In vivo: LPA was tested for its vascular remodeling effect in a rat model of hypoxic pulmonary hypertension. Serum from animals in the hypoxic group showed higher chemoattractant properties toward rat primary lung fibroblasts, and such cell migration increase was prevented by the LPA receptor 1 and 3 antagonists. LPA also found to increase adhesive properties of human pulmonary artery endothelial cells, via the activation of LPA receptor 1 or 3 [1].

Clinical trial: Clinical retults showed that LPA concentration was significantly higher in pancreatic cancer patients. For diagnosis of pancreatic cancer, the sensitivity of LPA was 89.6% and the specificity 79. 4%. However, plasma LPA alteration had shown significant correlations with the tumor size, pathological stage, surrounding lymph nodes, as well as specific histopathological features [2].

1-油酰赖氨酸磷脂酸（LPA）是一种天然存在的磷脂质，具有多种效应。LPA广泛分布于许多组织中。类似于许多其他生物调节剂，LPA通过特定的细胞表面受体与细胞相互作用，如G蛋白偶联受体，诱导生物效应。

体外研究：LPA可通过Edg/LPA受体介导信号转导，诱导肿瘤细胞的增殖、迁移、粘附和抗凋亡功能。此外，发现LPA能够诱导VEGF上调，从而对肿瘤的发生和发展产生间接影响。LPA还可刺激基质金属蛋白酶分泌和肿瘤血管生成因子[1]。

体内研究：在大鼠缺氧性肺动脉高压模型中，LPA被测试其对血管重构的作用。从缺氧组动物的血清中提取的成分对大鼠原代肺成纤维细胞具有更高的趋化作用，而这种细胞迁移增加可以被LPA受体1和3的拮抗剂预防。LPA也发现能够通过激活LPA受体1或3，增加人肺动脉内皮细胞的粘附性[1]。

临床试验：临床结果表明，胰腺癌患者的LPA浓度明显较高。对于胰腺癌的诊断，LPA的敏感性为89.6%，特异性为79.4%。然而，血浆LPA的变化与肿瘤大小、病理分期、周围淋巴结以及特定的组织病理学特征显示有显著相关性[2]。

参考文献:
[1] Yongling G, Shaokai W, Chenjie T, Jinfei C, Shukui W, Xiufeng C, Guangmei L, Pin L.? Clinical evaluation on the determination of plasma lysophosphatidic acid concentration in Chinese human pancreatic cancer. International Journal of Hepatobiliary and Pancreatic Diseases 2011;1:6-12.
[2] Shlyonsky V,Naeije R,Mies F.? Possible role of lysophosphatidic acid in rat model of hypoxic pulmonary vascular remodeling. Pulm Circ.2014 Sep;4(3):471-81.