Eliprodil

An NMDA receptor antagonist

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库存: 现货

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10mg

￥1037.00

830.00

- +
50mg

￥3887.00

3110.00

- +

已选 0 种 0 瓶

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货号: ajci14928
CAS: 119431-25-3
别名: 依利罗地,SL-820715
分子式: C20H23ClFNO
分子量: 347.86
纯度: >98%
溶解度: DMF: 10mg/mL,DMSO: 2mg/mL,Ethanol: 2mg/mL
储存: Store at -20°C
库存: 现货

Background

Eliprodil(SL-820715) is a non-competitive NR2B-NMDA receptor antagonist(IC50=1 uM), less potent for NR2A- and NR2C-containing receptors(IC50> 100 uM).IC50 value:Target: NR2B-NMDA antagonistHuman N-type Ca2+ channel currents were inhibited by ifenprodil and eliprodil with IC50 values of 50 microM and 10 microM respectively whereas P-type Ca2+ channel currents were inhibited reversibly by ifenprodil and eliprodil with approximate IC50 values of 60 microM and 9 microM respectively. eliprodil (1 microm) produced a moderate reverse rate-dependent prolongation of the action potential duration (7.4+/-1.5, 8.9+/-2.1 and 9.9+/-1.8% at cycle lengths of 300, 1000 and 5000 ms, respectively; n=9).

参考文献:
[1]. Bath CP, et al. The effects of ifenprodil and eliprodil on voltage-dependent Ca2+ channels and in gerbil global cerebral ischaemia. Eur J Pharmacol. 1996 Mar 28;299(1-3):103-12.
[2]. Lengyel C, et al. Effect of a neuroprotective drug, eliprodil on cardiac repolarisation: importance of the decreased repolarisation reserve in the development of proarrhythmic risk. Br J Pharmacol. 2004 Sep;143(1):152-8.